We establish Cramér-type moderate deviation theorems for sums of locally dependent random variables and combinatorial central limit theorems. Under some mild exponential moment conditions, optimal error bounds and convergence ranges are obtained. Our main results are more general or shaper than the existing results in the literature. The main results follows from a more general Cramér-type moderate deviation theorem for dependent random variables without any boundedness assumptions, which is of independent interest. The proofs combine Stein’s method with a recursive argument. This is a joint work with Song-Hao Liu.